
Wellcome Early Career Fellow
Wellcome Early Career Fellow at the Institute for Regeneration and Repair the University of Edinburgh.
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Using mass spectrometry-based mini-bulk and single cell proteomics to study neutrophil functional heterogeneity in health and chronic inflammatory disease with emphasis on COPD.
Research Interests
Proteins are the effector molecules which carry out most of the functions within cells and are the common targets of drugs. The set of proteins expressed by a cell or tissue is referred to as the proteome. This proteome is dynamic and constantly changes in response to stimuli through synthesis and degradation.​
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My research uses novel Mass Spectrometry-based methods, including single cell proteomics, to characterise the proteomes of neutrophils both in health and under chronic inflammatory conditions.
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I also have a strong interest in data sharing and re-use. To promote data sharing within proteomics but also with the wider research community, I created and maintain the Immunological Proteome Resource ( ImmPRes; immpres.co.uk).
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Publications
Sadiku P*, Brenes A.J.* - Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma - (2025) bioRxiv
Brenes A.J., Lamond A.I. & Cantrell D.A. - The Immunological Proteome Resource - (2023) Nature Immunology
Brenes A.J., et al - Multibatch TMT reveals false positives, batch effects and missing values - (2019) Molecular & Cellular Proteomics
