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Wellcome Early Career Fellow

Wellcome Early Career Fellow at the Institute for Regeneration and Repair the University of Edinburgh.

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Using mass spectrometry-based mini-bulk and single cell proteomics to study neutrophil functional heterogeneity in health and chronic inflammatory disease with emphasis on COPD.

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Research Interests

Proteins are the effector molecules which carry out most of the functions within cells and are the common targets of drugs. The set of proteins expressed by a cell or tissue is referred to as the proteome. This proteome is dynamic and constantly changes in response to stimuli through synthesis and degradation.​

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My research uses novel Mass Spectrometry-based methods, including single cell proteomics, to characterise the proteomes of neutrophils both in health and under chronic inflammatory conditions. 

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I also have a strong interest in data sharing and re-use. To promote data sharing within proteomics but also with the wider research community, I created and maintain the Immunological Proteome Resource ( ImmPRes; immpres.co.uk). 

 

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Contact

Publications

Brenes A.J., Lamond A.I. & Cantrell D.A. - The Immunological Proteome Resource - (2023) Nature Immunology

Brenes A.J., et al - Multibatch TMT reveals false positives, batch effects and missing values - (2019) Molecular & Cellular Proteomics

Contact
Information

Centre for Inflammation Research

Institute for Regeneration and Repair

University of Edinburgh

5 Little France Dr, Edinburgh, EH16 4UU

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©2021-5 by Alejandro J. Brenes

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