Alejandro J. Brenes
Postdoctoral Researcher - Granulocyte proteomics
I'm a Postdoctoral researcher at the Walmsley lab within the Centre for Inflammation Research at the University of Edinburgh. My main area of research lies in using cutting edge proteomics to study human granulocytes in health and chronic inflammation.
Research Interests
Proteins are the effector molecules which carry out most of the functions within cells and are the common targets of drugs. The set of proteins expressed by a cell or tissue is referred to as the proteome. This proteome is dynamic and constantly changes in response to stimuli through synthesis and degradation.​
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My research uses novel Mass Spectrometry methods, including single cell proteomics, to characterise the proteomes of human granulocytes both in health and under chronic inflammatory conditions.
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I also have a strong interest in data sharing and re-use. To promote data sharing within proteomics but also with the wider research community, I created and maintain the community resource called the Immunological Proteome Resource ( ImmPRes; immpres.co.uk).
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Publications
Long, M.B. ... & Brenes A.J. - Extensive acute and sustained changes to neutrophil proteomes post-SARS-CoV-2 infection - (2024) European Respiratory Journal
Brenes A.J., Lamond A.I. & Cantrell D.A. - The Immunological Proteome Resource - (2023) Nature Immunology
Brenes A.J., et al - Multibatch TMT reveals false positives, batch effects and missing values - (2019) Molecular & Cellular Proteomics